The research conducted by Professor Iris Bell (MD, PhD) and Professor Jayesh Bellare (PhD) has significantly advanced the scientific understanding of homeopathy, particularly addressing the long-standing question: How can ultra-diluted homeopathic remedies exert effects if no molecules of the original substance remain?
Their independent but complementary research provides empirical support for the nanoparticle hypothesis—a key bridge between classical homeopathy and modern materials science.
🔬 1. Professor Jayesh Bellare’s Research (IIT Bombay): Nanoparticles in High Dilutions
Bellare and his team used transmission electron microscopy (TEM), dynamic light scattering (DLS), and electron diffraction techniques to analyze high-dilution homeopathic remedies (such as 30C and 200C potencies).
✅ Key Findings:
- Nanoparticles of the original source material were found even in remedies diluted beyond Avogadro’s number (where conventional chemistry predicts no molecules should remain).
- These nanoparticles were coated with a unique “biogenic” silica layer, likely from the glass containers used during succussion (vigorous shaking).
- Succussion plays a crucial role in nanoparticle formation, embedding the medicinal source material into nanostructured carriers.
📌 Implication:
- Homeopathic dilutions are not just chemically inert water—they are colloidal nanostructures with source-specific identity and information.
- Nanoparticles can interact with biological systems, affecting gene expression, protein synthesis, and immune responses—even in ultra-low concentrations.
🧠 2. Professor Iris Bell’s Research (University of Arizona): Adaptive Network Regulation
Dr. Iris Bell, trained in both psychiatry and immunology, contributed a systems biology framework for understanding how homeopathy might work within the human body’s adaptive networks (nervous, endocrine, and immune systems).
✅ Key Concepts:
- Nanoparticles act as low-dose stressors, triggering hormetic responses—a well-known biological principle where small doses stimulate healing/adaptation.
- These responses affect complex adaptive systems in the body rather than linear dose-response pathways.
- Bell proposes that homeopathic remedies modulate allostatic load, restoring balance in systems under chronic stress or dysregulation.
📌 Implication:
- Homeopathy works not by a direct pharmacological mechanism but by stimulating systemic self-regulation via nanoparticle information carriers.
- Remedies function like informational signals, not chemicals—a view consistent with quantum biology and information theory.
🧩 Synthesizing Bell and Bellare:
| Aspect | Professor Jayesh Bellare | Professor Iris Bell |
|---|---|---|
| Field | Nanotechnology | Psychoneuroimmunology / Systems Biology |
| Core Finding | Nanoparticles persist in homeopathic remedies | Remedies interact with complex adaptive systems |
| Methodology | Electron microscopy, materials analysis | Theoretical modeling, literature synthesis, clinical perspectives |
| Implication | Physical structure exists at nano-scale | Remedies influence systemic regulation (hormesis, information transfer) |
| Shared Theme | Homeopathic remedies contain nanostructures that convey biological signals to the body |
🌐 Conclusion
Together, the work of Bell and Bellare substantiates a material basis and a biological mechanism for homeopathy:
- Remedies may carry informational imprints of the original substance via nanoparticles.
- These structures can interact with the body’s regulatory networks, leading to therapeutic effects.
- This model helps reconcile homeopathy with modern science, particularly nanomedicine, systems biology, and epigenetics.
interviews with Professors Iris Bell and Jayesh Bellare are available to view within this Hub